PRO: Stunning and hibernation: two faces of the same disease
نویسنده
چکیده
منابع مشابه
Hibernation or repetitive stunning – does it matter? The basic perspective
The long-lasting controversy on whether the contractile dysfunction observed in patients with coronary artery disease reflects hibernation – that is, a regulatory adaptation to persistent ischemia – or stunning – that is, an accumulation of reversible damage due to repeated periods of ischemia/reperfusion – is resolved. The perfect adaptation to persistent ischemia as seen experimentally can no...
متن کاملMyocardial Stunning with Hemodialysis: Clinical Challenges of the Cardiorenal Patient.
We discuss the current state of knowledge related to the pathogenesis of myocardial stunning as well as the potential mechanisms responsible for the clinical presentation of myocardial stunning in hemodialysis patients. We suggest future research areas for this critical and clinically important condition in this high-risk patient population. In consideration of acute and chronic changes seconda...
متن کاملIschemic Heart Failure: Radionuclide Imaging and Clinical Implications
Ischemic heart failure: pathophysiological aspects Under certain conditions, when viable myocytes are subject to ischemia, prolonged alterations in regional or global LV function may occur and this dysfunction may be completely reversible. This condition may be related to two pathophysiological states: stunned and hibernating myocardium. Stunned myocardium refers to the state of persistent regi...
متن کاملCardioprotection: nitric oxide, protein kinases, and mitochondria.
Over the past 2 to 3 decades, several phenomena have been identified that provide powerful protection against myocardial infarction and other sequelae of ischemia/reperfusion1: myocardial hibernation that is related to stunning,2 ischemic preconditioning,3 delayed or second-window ischemic preconditioning,4 ischemic postconditioning,5 and their pharmacological recruitment. Stunning and hibernat...
متن کاملTracing ischemic memory by metabolic pathways: BMIPP and beyond
Myocardial ischemia (MI) resulting in infarction is an important cause of mortality and morbidity worldwide. Acute ischaemia rapidly impairs myocardial contractile function. Myocardial dysfunction persisting for several hours after transient non-lethal ischaemia, eventually resulting in full functional recovery is termed as myocardial stunning. Hibernation is now thought to be...
متن کامل